Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
نویسندگان
چکیده
منابع مشابه
Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions.
The mitochondrial generation of reactive oxygen species (ROS) plays a central role in many cell signaling pathways, but debate still surrounds its regulation by factors, such as substrate availability, [O2] and metabolic state. Previously, we showed that in isolated mitochondria respiring on succinate, ROS generation was a hyperbolic function of [O2]. In the current study, we used a wide variet...
متن کاملMitochondrial metabolism of reactive oxygen species.
For a long time mitochondria have mainly been considered for their role in the aerobic energy production in eukaryotic cells, being the sites of the oxidative phosphorylation, which couples the electron transfer from respiratory substrates to oxygen with the ATP synthesis. Subsequently, it was showed that electron transfer along mitochondrial respiratory chain also leads to the formation of rad...
متن کاملUpdate on Mitochondrial Reactive Oxygen Species Mitochondrial Reactive Oxygen Species. Contribution to Oxidative Stress and Interorganellar Signaling
The inner membrane of a plant mitochondrion contains the mitochondrial electron transport chain (mtETC), consisting of protein complexes that use an energy source-derived reductant to form a proton gradient across the membrane. This proton gradient drives ATP synthesis, a primary mitochondrial function. Ultimately, electrons in the mtETC are transferred through one of two pathways from ubiquino...
متن کاملMitochondrial reactive oxygen species and Ca signaling
Camello-Almaraz, Cristina, Pedro J. Gomez-Pinilla, Maria J. Pozo, and Pedro J. Camello. Mitochondrial reactive oxygen species and Ca signaling. Am J Physiol Cell Physiol 291: C1082–C1088, 2006; doi:10.1152/ajpcell.00217.2006.—Mitochondria are an important source of reactive oxygen species (ROS) formed as a side product of oxidative phosphorylation. The main sites of oxidant production are compl...
متن کاملMitochondrial reactive oxygen species and Ca2+ signaling.
Mitochondria are an important source of reactive oxygen species (ROS) formed as a side product of oxidative phosphorylation. The main sites of oxidant production are complex I and complex III, where electrons flowing from reduced substrates are occasionally transferred to oxygen to form superoxide anion and derived products. These highly reactive compounds have a well-known role in pathological...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science Advances
سال: 2020
ISSN: 2375-2548
DOI: 10.1126/sciadv.abb7272